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SKIL / SNO / SnoN
SKI-like oncogene
SKIL / SNO / SnoN is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.
| Gene Name: | SKI-like oncogene |
| Synonyms: | SKIL, Ski-related oncogene, SnoI, SnoN, SKI-like oncogene, Sno, Ski-related oncogene snoN, Ski-related protein, Ski-like protein, SnoA |
| Target Sequences: | NM_005414 NP_005405.2 P12757 |
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