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SKAP2 / SCAP2
src kinase associated phosphoprotein 2
SKAP2 / SCAP2 shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Gene Name: | src kinase associated phosphoprotein 2 |
| Synonyms: | SKAP2, RA70, SCAP2, SKAP-55HOM, PRAP, Pyk2/RAFTK-associated protein, SKAP55R, Src-associated adaptor protein, SAPS, SKAP-HOM, SKAP55 homolog |
| Target Sequences: | NM_003930 NP_003921.2 O75563 |
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