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Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments.
Gene Name: | kinetochore-localized astrin/SPAG5 binding protein |
Synonyms: | KNSTRN, C15orf23, SKAP, TRAF4AF1, HSD11 |
Target Sequences: | W17330 |
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