SIX1

SIX homeobox 1

Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

SIX1 (5)

Publications

No (5)

Tag

GST (1)

His (1)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human SIX1 Protein (Recombinant His, N-Terminal) - LS-G144671

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

32 kDa

Price:

50 µg/$419

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Human SIX1 Protein (Recombinant GST) (Full Length) - LS-G30415

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

56.98 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SIX1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76610

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32 kDa

Price:

20 µg/$150

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SIX1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100698

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32 kDa

Price:

100 µg/$494

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Human SIX1 Protein (Recombinant His) - LS-G1945

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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