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SIX1

SIX homeobox 1

Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1.

Gene Name: SIX homeobox 1
Synonyms: SIX1, BOS3, DFNA23, Sine oculis homeobox homolog 1, SIX homeobox 1, TIP39, Homeobox protein SIX1
Target Sequences: NM_005982 NP_005973.1 Q15475

Filtered By: None
Type
Recombinant (3)
Target
six1 (3)
Tag
GST (1)
His (2)
Species
Human (3)
Source
E. coli (2)
Wheat Germ Extract (1)
Purification
Purified (3)
Showing 1-3 out of 3 results
Human SIX1 Protein (Recombinant His) - LS-G18893

E. coli
His
No
No known endotoxin level
34.7 kDa
Human SIX1 Protein (Recombinant His) - LS-G1945

E. coli
308 AA
His
No
No known endotoxin level
Human SIX1 Protein (Recombinant GST) - LS-G30415

Wheat Germ Extract
284 AA
GST
No
No known endotoxin level
56.98 kDa

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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