LSBio
LSBio
Products
Services
Research Areas
Resources
Contact Us
Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)

How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Products
Services
Research Areas
Resources
Contact Us

SIX1

SIX homeobox 1

Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1.

Gene Name: SIX homeobox 1
Synonyms: SIX1, BOS3, DFNA23, Sine oculis homeobox homolog 1, SIX homeobox 1, TIP39, Homeobox protein SIX1
Target Sequences: NM_005982 NP_005973.1 Q15475

Filtered By: None
Type
Over-Expression Lysate (2)
Recombinant (3)
Target
six1 (5)
Tag
GST (1)
His (2)
Myc + DDK (2)
Species
Human (4)
Source
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purification
Purified (3)
Showing 1-5 of 5 results

Human SIX1 Protein (Over-Expression Lysate Myc + DDK) - LS-G76610
293T Cells
336 AA
Myc + DDK
None
No known endotoxin level
32 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human SIX1 Protein (Recombinant His) - LS-G18893
E. coli
His
None
No known endotoxin level
34.7 kDa
5µg  $195.00; 20µg  $255.00; 1mg  $2,850.00

Human SIX1 Protein (Recombinant GST) (Full Length) - LS-G30415
Wheat Germ Extract
284 AA
GST
None
No known endotoxin level
56.98 kDa
10µg  $415.00; 25µg  $590.00
12.5% SDS-PAGE of human SIX1 stained with Coomassie Blue
12.5% SDS-PAGE of human SIX1 stained with Coomassie Blue

Human SIX1 Protein (Recombinant His) - LS-G1945
E. coli
308 AA
His
None
No known endotoxin level
500µg  $680.00; 100µg  $315.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

SIX1 Protein (Over-Expression Lysate Myc + DDK) - LS-G100698
HEK 293 Cells
336 AA
Myc + DDK
None
No known endotoxin level
32 kDa
100µg  $345.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Showing 1-5 of 5 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


Get Social With Us!
Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2018 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy