SIRT6 / Sirtuin 6

sirtuin 6

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate.

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Products

Proteins (10)

Type

Over-Expression Lysate (2)

Recombinant (8)

Target

SIRT6 / Sirtuin 6 (10)

Publications

No (10)

Tag

GST (1)

GST, N-terminus (2)

His (4)

Myc-DDK (Flag) (3)

Species

Human (7)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (5)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

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Human SIRT6 / Sirtuin 6 Protein (Recombinant His) (aa1-355) - LS-G15594

Source:

E. coli

Tag:

His

Molecular Weight:

44.8 kDa

Price:

10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,728

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Human SIRT6 / Sirtuin 6 Protein (Recombinant GST) (Full Length) - LS-G33816

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

62.5 kDa

Price:

2 µg/$439

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Human SIRT6 / Sirtuin 6 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69412

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.9 kDa

Price:

20 µg/$1,107

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Human SIRT6 / Sirtuin 6 Protein (Recombinant GST, N-terminus) (aa141-250) - LS-G62498

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SIRT6 / Sirtuin 6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84577

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.9 kDa

Price:

20 µg/$150

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SIRT6 / Sirtuin 6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101446

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.9 kDa

Price:

100 µg/$494

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Human SIRT6 / Sirtuin 6 Protein (Recombinant His) - LS-G3551

Source:

E. coli

Tag:

His

Price:

100 µg/$511; 500 µg/$1,348; 20 µg/$311

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Mouse SIRT6 / Sirtuin 6 Protein (Recombinant His) (aa1-334) - LS-G15595

Source:

E. coli

Tag:

His

Molecular Weight:

38.4 kDa

Price:

10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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Rat SIRT6 / Sirtuin 6 Protein (Recombinant His) (aa88-288) - LS-G15602

Source:

E. coli

Tag:

His

Molecular Weight:

23.8 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human SIRT6 / Sirtuin 6 Protein (Recombinant GST, N-terminus) (aa1-355) - LS-G56884

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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