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SIRT3 / Sirtuin 3

sirtuin 3

SIRT3 / Sirtuin 3 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Gene Name: sirtuin 3
Family/Subfamily: ADP-Ribosyltransferase , not assigned-ADP-Ribosyltransferase
Synonyms: SIRT3, HSIRT3, Sir2-like 3, SIR2-like protein 3, SIR2L3, Sirtuin 3, Sirtuin type 3
Target Sequences: NM_012239 NP_036371.1 Q9NTG7

Publications (2)

1
FoxO1 mediates an autofeedback loop regulating SIRT1 expression. Xiong S, Salazar G, Patrushev N, Alexander RW. The Journal of biological chemistry. 2011 286:5289-99. [PubMed:21149440] [PMC:PMC3037641] Related Antibodies: LS-C100489.
2
Integration of -catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity. Parker JA, Vazquez-Manrique RP, Tourette C, Farina F, Offner N, Mukhopadhyay A, Orfila AM, Darbois A, Menet S, Tissenbaum HA, Neri C. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:12630-40. [PubMed:22956852] Related Antibodies: LS-C100489.

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SIRT3 / Sirtuin 3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
SIRT3 / Sirtuin 3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SIRT3 / Sirtuin 3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$854
SIRT3 / Sirtuin 3 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
SIRT3 / Sirtuin 3 ELISA Kit
Select
Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$672
SIRT3 / Sirtuin 3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$893
SIRT3 / Sirtuin 3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).