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SIGLEC1 / CD169 / Sialoadhesin

sialic acid binding Ig-like lectin 1, sialoadhesin

Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.

Gene Name: sialic acid binding Ig-like lectin 1, sialoadhesin
Family/Subfamily: Immunoglobulin , not assigned-Immunoglobulin
Synonyms: SIGLEC1, CD169, CD169 antigen, SIGLEC-1, Sialoadhesin, SN, DJ1009E24.1
Target Sequences: NM_023068 NP_075556.1 Q9BZZ2

Publications (6)

1
The species-specific structure of microanatomical compartments in the human spleen: strongly sialoadhesin-positive macrophages occur in the perifollicular zone, but not in the marginal zone. Steiniger B, Barth P, Herbst B, Hartnell A, Crocker PR. Immunology. 1997 92:307-16. [PubMed:9415041] [PMC:PMC1364073]
2
Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. Hartnell A, Steel J, Turley H, Jones M, Jackson DG, Crocker PR. Blood. 2001 97:288-96. (IHC) [PubMed:11133773]
3
Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury. Leaf IA, Nakagawa S, Johnson BG, Cha JJ, Mittelsteadt K, Guckian KM, Gomez IG, Altemeier WA, Duffield JS. The Journal of clinical investigation. 2017 127:321-334. (Flo; Mouse) [Full Text Article] [PubMed:27869651] [PMC:PMC5199713] Related Antibodies: LS-C188785.
4
Aggressive rat prostate tumors reprogram the benign parts of the prostate and regional lymph nodes prior to metastasis. Strömvall K, Thysell E, Halin Bergström S, Bergh A. PloS one. 2017 12:e0176679. (IP; Rat) [Full Text Article] [PubMed:28472073] [PMC:PMC5417597] Related Antibodies: LS-C124538.
5
Reduced number of CD169+macrophages in pre-metastatic regional lymph nodes is associated with subsequent metastatic disease in an animal model and with poor outcome in prostate cancer patients. Strömvall K, Sundkvist K, Ljungberg B, Halin Bergström S, Bergh A. The Prostate. 2017 November;77:1468-1477. (Rat) [Full Text Article] [PubMed:28880401] [PMC:PMC5656907] Related Antibodies: LS-C124538.
6
Porcine sialoadhesin suppresses type I interferon production to support porcine reproductive and respiratory syndrome virus infection. Yingqi Liu, Rui Li, Songlin Qiao, Xin-Xin Chen, Ruiguang Deng, Gaiping Zhang. Veterinary Research. 2020 February;51:18. [Full Text Article] [PubMed:32093750] [PMC:PMC7038599] Related Antibodies: LS-C187491.
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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
SIGLEC1 / CD169 / Sialoadhesin (5)
No (5)
His (1)
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Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
SIGLEC1 / CD169 / Sialoadhesin Protein
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Human SIGLEC1 / CD169 / Sialoadhesin Protein (Recombinant His, N-Terminal) (aa34-240) - LS-G13154
E. coli
His, N-Terminal
25.0 kDa
10 µg/$265; 50 µg/$347; 200 µg/$682; 1 mg/$1,690; 5 mg/$2,637; 2 mg/$1,866
SIGLEC1 / CD169 / Sialoadhesin Protein - Recombinant Sialic Acid Binding Ig Like Lectin 1 By SDS-PAGE
Select
Human SIGLEC1 / CD169 / Sialoadhesin Protein (Recombinant His) (aa1272-1411) - LS-G13152
E. coli
His
16.2 kDa
10 µg/$265; 50 µg/$347; 200 µg/$682; 1 mg/$1,690; 5 mg/$2,637; 2 mg/$1,866
SIGLEC1 / CD169 / Sialoadhesin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
SIGLEC1 / CD169 / Sialoadhesin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110187
HEK 293 Cells
Myc-DDK (Flag)
180.6 kDa
100 µg/$710
SIGLEC1 / CD169 / Sialoadhesin Protein - Purified recombinant protein SIGLEC1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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Human SIGLEC1 / CD169 / Sialoadhesin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69860
HEK 293 Cells
Myc-DDK (Flag)
180.6 kDa
20 µg/$1,107
SIGLEC1 / CD169 / Sialoadhesin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
Human SIGLEC1 / CD169 / Sialoadhesin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85700
293T Cells
Myc-DDK (Flag)
180.6 kDa
20 µg/$215
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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