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SIGLEC1 / CD169 / Sialoadhesin
sialic acid binding Ig-like lectin 1, sialoadhesin
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.
| Gene Name: | sialic acid binding Ig-like lectin 1, sialoadhesin |
| Family/Subfamily: | Immunoglobulin , not assigned-Immunoglobulin |
| Synonyms: | SIGLEC1, CD169, CD169 antigen, SIGLEC-1, Sialoadhesin, SN, DJ1009E24.1 |
| Target Sequences: | NM_023068 NP_075556.1 Q9BZZ2 |
Publications (6)
1
The species-specific structure of microanatomical compartments in the human spleen: strongly sialoadhesin-positive macrophages occur in the perifollicular zone, but not in the marginal zone. Steiniger B, Barth P, Herbst B, Hartnell A, Crocker PR. Immunology. 1997 92:307-16.
[PubMed:9415041]
[PMC:PMC1364073]
2
Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. Hartnell A, Steel J, Turley H, Jones M, Jackson DG, Crocker PR. Blood. 2001 97:288-96. (IHC)
[PubMed:11133773]
3
Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury. Leaf IA, Nakagawa S, Johnson BG, Cha JJ, Mittelsteadt K, Guckian KM, Gomez IG, Altemeier WA, Duffield JS. The Journal of clinical investigation. 2017 127:321-334. (Flo; Mouse)
[Full Text Article]
[PubMed:27869651]
[PMC:PMC5199713]
Related Antibodies: LS-C188785.
☰ Filters
Products
ELISA Kits
(15)
Type
Custom
(1)
Sandwich
(13)
Sandwich CLIA
(1)
Target
SIGLEC1 / CD169 / Sialoadhesin
(15)
Reactivity
Human
(7)
Mouse
(2)
Chicken
(1)
Guinea pig
(1)
Monkey
(1)
Porcine
(1)
Rabbit
(1)
Sheep
(1)
Format
12 x 8-Well Microstrips
(1)
96-Well Microplate
(4)
96-Well Strip Plate
(10)
Publications
No
(15)
Sample Type
Cell Culture Supernatants
(4)
Plasma
(8)
Serum
(8)
Tissue Homogenates
(2)
Sandwich
96-Well Strip Plate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$717
Sandwich
96-Well Strip Plate
Chicken
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
Sandwich
96-Well Strip Plate
Guinea pig
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
Sandwich
96-Well Strip Plate
Sheep
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$760
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$1,150
Sandwich
96-Well Microplate
Mouse
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$1,150
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Mouse
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$717
Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$700
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$764
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