SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.

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Products

Proteins (19)

Type

Over-Expression Lysate (6)

Recombinant (13)

Target

SIGIRR (19)

Publications

No (19)

Tag

6His, N-terminus (1)

6His-SUMO, N-terminus (1)

Fc (1)

GST (1)

His (3)

His-Fc (1)

His-GST (1)

Human IgG1 Fc, C-terminus (1)

Myc-DDK (Flag) (9)

Species

Human (11)

Mouse (4)

Rat (1)

Source

293T Cells (3)

E. coli (4)

HEK 293 Cells (7)

Human Cells (3)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (5)

Low Endotoxin Level

Low endotoxin level (4)

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SIGIRR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125383

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.5 kDa

Price:

100 µg/$494

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SIGIRR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125384

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.5 kDa

Price:

100 µg/$494

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Human SIGIRR Protein (Recombinant Human IgG1 Fc, C-terminus) - LS-G134352

Source:

HEK 293 Cells

Tag:

Human IgG1 Fc, C-terminus

Endotoxin Level:

Less than 0.06 EU/µg protein (determined by LAL method).

Molecular Weight:

~50 kDa (SDS-PAGE)

Price:

10 µg/$309; 50 µg/$414

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Human SIGIRR Protein (Recombinant GST) (Full Length) - LS-G34855

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

70.84 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse SIGIRR Protein (Recombinant 6His, N-terminus) (aa1-117) - LS-G57370

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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Mouse SIGIRR Protein (Recombinant 6His-SUMO, N-terminus) (aa1-117) - LS-G56987

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Human SIGIRR Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68569

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.5 kDa

Price:

20 µg/$1,107

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Human SIGIRR Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68566

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.5 kDa

Price:

20 µg/$1,107

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Human SIGIRR Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68567

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.5 kDa

Price:

20 µg/$1,107

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Human SIGIRR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82515

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.5 kDa

Price:

20 µg/$150

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Human SIGIRR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82514

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.5 kDa

Price:

20 µg/$150

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Human SIGIRR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82516

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.5 kDa

Price:

20 µg/$150

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SIGIRR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101760

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.5 kDa

Price:

100 µg/$494

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Human SIGIRR Protein (Recombinant Fc) (Met1-His118) - LS-G97889

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

39.5 kDa

Price:

100 µg/$793; 1 mg/$4,191

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Human SIGIRR Protein (Recombinant His) (aa1-118) - LS-G16211

Source:

E. coli

Tag:

His

Molecular Weight:

14.1 kDa

Price:

10 µg/$252; 50 µg/$315; 100 µg/$417; 200 µg/$522; 1 mg/$1,404; 500 µg/$1,034; 5 mg/$2,303; 2 mg/$1,565

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Rat SIGIRR Protein (Recombinant His) (aa1-118) - LS-G16214

Source:

E. coli

Tag:

His

Molecular Weight:

14.3 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Mouse SIGIRR Protein (Recombinant His-GST) (aa1-117) - LS-G16212

Source:

E. coli

Tag:

His-GST

Molecular Weight:

39.7 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

Select

Human SIGIRR Protein (Recombinant His) (Met1-His118) - LS-G97888

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

14 kDa

Price:

100 µg/$793; 1 mg/$4,191

Select

Mouse SIGIRR Protein (Recombinant His-Fc) (Met1-His117) - LS-G98278

Source:

Human Cells

Tag:

His-Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

40.7 kDa

Price:

100 µg/$926

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