SIAH2

siah E3 ubiquitin protein ligase 2

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not. Promotes monoubiquitination of SNCA.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

SIAH2 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human SIAH2 Protein (Recombinant GST, N-terminus) (aa225-324) - LS-G60093

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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SIAH2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116217

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.4 kDa

Price:

100 µg/$494

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Human SIAH2 Protein (Recombinant GST) (Full Length) - LS-G30409

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

61 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SIAH2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68272

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.4 kDa

Price:

20 µg/$1,107

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Human SIAH2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81799

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.4 kDa

Price:

20 µg/$150

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