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The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. After endocytosis, the A subunit is cleaved by furin in two fragments, A1 and A2: A1 is the catalytically active fragment, and A2 is essential for holotoxin assembly with the B subunits.
Gene Name: | Shiga Toxin 1 A Subunit (SLT1A) |
Synonyms: | ECs2974, Shiga-like toxin 1 subunit A, SLT1A |
Target Sequences: | P10149 P10149 |
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