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Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Gene Name: | Src homology 2 domain containing adaptor protein B |
Synonyms: | SHB, BA3J10.2, RP11-3J10.8 |
Target Sequences: | NM_003028 NP_003019.2 Q15464 |
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