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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SHANK2 / SHANK

SH3 and multiple ankyrin repeat domains 2

SHANK2 / SHANK is a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants.

Gene Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: SHANK2, AUTS17, Cortactin binding protein 1, CTTNBP1, CORTBP1, SPANK-3, SHANK, Cortactin-binding protein 1, GKAP/SAPAP interacting protein, KIAA1022, ProSAP1
Target Sequences: NM_012309 NP_036441.2 Q9UPX8

Filtered by: None
Target
SHANK2 / SHANK (63)
Reactivity
Human (57)
Mouse (48)
Rat (41)
Bovine (4)
Chimpanzee (6)
Gibbon (6)
Horse (4)
Monkey (4)
Orangutan (3)
Application
IHC (40)
IHC-P (3)
WB (58)
ELISA (9)
ICC (36)
IF (35)
IP (36)
Peptide-ELISA (2)
Host
rabbit (25)
mouse (37)
sheep (1)
Isotype
IgG (16)
IgG1 (37)
Clonality
monoclonal mc (37)
polyclonal pc (26)
Clone
S23b-49 (18)
S23b-6 (18)
Format
AP Conjugated (3)
APC Conjugated (3)
Atto 390 Conjugated (2)
Atto 488 Conjugated (2)
Atto 565 Conjugated (2)
Atto 594 Conjugated (4)
Atto 633 Conjugated (2)
Atto 655 Conjugated (2)
Atto 680 Conjugated (2)
Atto 700 Conjugated (2)
Azide-free (1)
Biotin Conjugated (6)
FITC Conjugated (6)
HRP Conjugated (4)
PE (2)
PE Conjugated (1)
PerCP Conjugated (2)
RPE Conjugated (2)
SA Conjugated (2)
Unconjugated (16)
Epitope
aa84-309 (37)
aa879-908 (8)
aa1057-1106 (4)
aa1446-1495 (4)
300-380 aa, Internal (1)
Internal (1)
aa322-371 (1)
aa331-380 (1)
aa849-1029 (1)
Publications
No (63)
Showing 1-25 of 63 results

IHC-plus™ SHANK2 / SHANK Antibody (aa331-380) LS-B9264
Rabbit Polyclonal (IgG) to Human SHANK2 / SHANK
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-SHANK2 / SHANK antibody IHC staining of human intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Western blot analysis of lysates from RAW264.7, Jurkat, HepG2, and COLO cells, using SHANK2 Antibody. The lane on the right is blocked with the synthesized peptide.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-6) LS-C109025
Mouse Monoclonal [clone S23b-6] (IgG1) to Rat SHANK2 / SHANK
Rat, Human
ICC, IHC, IP, WB
Unconjugated
100µg  $365.00
Western blot analysis of Shank2 in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-6, Atto 390) LS-C231589
Mouse Monoclonal [clone S23b-6] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 390 Conjugated
100µg  $395.00
Western blot analysis of Shank2 in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-6, Atto 655) LS-C231594
Mouse Monoclonal [clone S23b-6] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 655 Conjugated
100µg  $395.00
Western blot analysis of Shank2 in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-6, Atto 488) LS-C231590
Mouse Monoclonal [clone S23b-6] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 488 Conjugated
100µg  $395.00
Western blot analysis of Shank2 in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-6, Atto 594) LS-C231592
Mouse Monoclonal [clone S23b-6] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 594 Conjugated
100µg  $395.00
Western blot analysis of Shank2 in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ SHANK2 / SHANK Antibody (aa322-371) LS-B14703
Rabbit Polyclonal (IgG) to Human SHANK2 / SHANK
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $425.00
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western blot analysis of the lysates from HT-29 cells using SHANK2 antibody.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49) LS-C153134
Mouse Monoclonal [clone S23b-49] (IgG1) to Human SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
100µg  $425.00

SHANK2 / SHANK Antibody (aa84-309, clone S23b-6) LS-C153132
Mouse Monoclonal [clone S23b-6] (IgG1) to Human SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
100µg  $425.00
Brain membranes from whole rat (RBM) and mouse (MBM) brain and from human (HBM) cerebral cortex and hippocampus.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, Biotin) LS-C230848
Mouse Monoclonal [clone S23b-49] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Biotin Conjugated
100µg  $395.00
Western blot analysis of pan-Shank in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, FITC) LS-C230849
Mouse Monoclonal [clone S23b-49] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
FITC Conjugated
100µg  $395.00
Western blot analysis of pan-Shank in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, Atto 633) LS-C230842
Mouse Monoclonal [clone S23b-49] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 633 Conjugated
100µg  $395.00
Western blot analysis of pan-Shank in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, Atto 488) LS-C230839
Mouse Monoclonal [clone S23b-49] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 488 Conjugated
100µg  $395.00
Western blot analysis of pan-Shank in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, PE, Atto 594) LS-C230850
Mouse Monoclonal [clone S23b-49] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
PE, Atto 594 Conjugated
100µg  $405.00
Western blot analysis of pan-Shank in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, Atto 680) LS-C230845
Mouse Monoclonal [clone S23b-49] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 680 Conjugated
100µg  $395.00
Western blot analysis of pan-Shank in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, Atto 594) LS-C230841
Mouse Monoclonal [clone S23b-49] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 594 Conjugated
100µg  $395.00
Western blot analysis of pan-Shank in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, RPE) LS-C230853
Mouse Monoclonal [clone S23b-49] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
RPE Conjugated
100µg  $395.00
Western blot analysis of pan-Shank in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, Atto 565) LS-C230840
Mouse Monoclonal [clone S23b-49] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 565 Conjugated
100µg  $395.00
Western blot analysis of pan-Shank in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, PerCP) LS-C230852
Mouse Monoclonal [clone S23b-49] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
PerCP Conjugated
100µg  $395.00
Western blot analysis of pan-Shank in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, Atto 655) LS-C230843
Mouse Monoclonal [clone S23b-49] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 655 Conjugated
100µg  $395.00
Western blot analysis of pan-Shank in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, APC) LS-C230847
Mouse Monoclonal [clone S23b-49] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
APC Conjugated
100µg  $395.00
Western blot analysis of pan-Shank in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, Atto 390) LS-C230838
Mouse Monoclonal [clone S23b-49] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 390 Conjugated
100µg  $395.00
Western blot analysis of pan-Shank in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, Atto 700) LS-C230844
Mouse Monoclonal [clone S23b-49] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 700 Conjugated
100µg  $395.00
Western blot analysis of pan-Shank in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, AP) LS-C230846
Mouse Monoclonal [clone S23b-49] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
AP Conjugated
100µg  $395.00
Western blot analysis of pan-Shank in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SHANK2 / SHANK Antibody (aa84-309, clone S23b-49, SA) LS-C230854
Mouse Monoclonal [clone S23b-49] (IgG1) to Rat SHANK2 / SHANK
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
SA Conjugated
100µg  $395.00
Western blot analysis of pan-Shank in rat brain membrane lysates using a 1:1000 dilution of SHANK2 / SHANK antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Showing 1-25 of 63 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).