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Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac.
Gene Name: | SH3-domain binding protein 1 |
Synonyms: | SH3BP1, 3BP-1, ARHGAP43, SH3-domain binding protein 1, SH3 domain binding protein 1, SH3 domain-binding protein 1 |
Target Sequences: | NM_018957 NP_061830.3 Q9Y3L3 |
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