SH2B1

SH2B adaptor protein 1

Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis.

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Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

SH2B1 (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (5)

Species

Human (5)

Source

293T Cells (2)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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SH2B1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G126830

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.2 kDa

Price:

100 µg/$710

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Human SH2B1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87400

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.2 kDa

Price:

20 µg/$215

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Human SH2B1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87401

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.6 kDa

Price:

20 µg/$215

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SH2B1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113185

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.6 kDa

Price:

100 µg/$710

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Human SH2B1 Protein (Recombinant GST) (Full Length) - LS-G33048

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

71.8 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SH2B1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70548

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.2 kDa

Price:

20 µg/$1,107

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Human SH2B1 Protein (Recombinant GST, N-terminus) (aa327-426) - LS-G62120

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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