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SFTPC / Surfactant Protein C

surfactant protein C

SFTPC / Surfactant Protein C is the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.

Gene Name: surfactant protein C
Synonyms: SFTPC, BRICD6, PSP-C, Pulmonary surfactant protein C, SMDP2, SFTP2, SP-C, Surfactant protein C
Target Sequences: NM_003018 NP_003009.2 P11686

Publications (5)

1
Optimization of Variable Ventilation for Physiology, Immune Response and Surfactant Enhancement in Preterm Lambs. Bartolák-Suki E, Noble PB, Bou Jawde S, Pillow JJ, Suki B. Frontiers in physiology. 2017 8:425. (WB; Human) [Full Text Article] [PubMed:28690548] [PMC:PMC5481362]
2
Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung. Yina Du, Geremy C Clair, Denise Al Alam, Soula Danopoulos, Daniel Schnell, Joseph A Kitzmiller, Ravi S Misra, Soumyaroop Bhattacharya, David Warburton, Thomas J Mariani, Gloria S Pryhuber, Jeffrey A Whitsett, Charles Ansong, Yan Xu. American journal of physiology. Lung cellular and molecular physiology. 2019 September;317:L347-L360. [Full Text Article] [PubMed:31268347] [PMC:PMC6766718] Related Antibodies: LS-B10952.
3
Generation of Complete Multi-Cell Type Lung Organoids From Human Embryonic and Patient-Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation. Sandra L Leibel, Rachael N McVicar, Alicia M Winquist, Walter D Niles, Evan Y Snyder. Current protocols in stem cell biology. 2020 September;54:e118. [Full Text Article] [PubMed:32640120] [PMC:PMC7361156] Related Antibodies: LS-B9161.
4
Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia10<sup> University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Pathology, Cologne, Germany12<sup> Dept of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany14<sup> University of Cologne, Faculty of Medicine and University Hospital Cologne, Translation. Dharmesh Hirani , Cristina M Alvira, Soula Danopoulos, Carlos Milla, Michele Donato, Lu Tian, Jasmine Mohr , Katharina Dinger , Christina Vohlen , Jaco Selle, Silke V Koningsbruggen-Rietschel, Verena Barbarino, Christian Pallasch, Stefan Rose-John, Margarete Odenthal, Gloria S Pryhuber, Siavash Mansouri, Rajkumar Savai , Werner Seeger , Purvesh Khatri, Denise Al Alam, Jörg Dötsch, Miguel A Alejandre Alcazar. The European respiratory journal. 2022 Feb;59:2002248. [Full Text Article] [PubMed:34446466] [PMC:PMC8850688] Related Antibodies: LS-B10952.
5
Hedgehog-responsive PDGFRa(+) fibroblasts maintain a unique pool of alveolar epithelial progenitor cells during alveologenesis. Feng Gao, Changgong Li, Soula Danopoulos, Denise Al Alam, Neil Peinado, Sha Webster, Zea Borok, GoleNaz Adeli Kohbodi, Saverio Bellusci, Parviz Minoo. Cell reports. 2022 April;39:110608. [Full Text Article] [PubMed:35385750] [PMC:PMC9199394] Related Antibodies: LS-B10952.
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ELISA Kits (18)
Competitive EIA (2)
Custom (3)
Sandwich (12)
Sandwich CLIA (1)
SFTPC / Surfactant Protein C (18)
Human (5)
Mouse (4)
Rat (6)
Bovine (1)
Dog (1)
Pig (1)
12 x 8-Well Microstrips (1)
96-Well Microplate (2)
96-Well Strip Plate (15)
No (18)
Cell Culture Supernatants (2)
Cell Lysates (3)
Lung Lavage Fluid (2)
Plasma (13)
Serum (13)
Tissue Homogenates (7)
SFTPC / Surfactant Protein C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Lung Lavage Fluid, Plasma, Serum, Tissue Homogenates
1 Plate/$798
SFTPC / Surfactant Protein C ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
SFTPC / Surfactant Protein C ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.469 - 30 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
SFTPC / Surfactant Protein C ELISA Kit
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Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
SFTPC / Surfactant Protein C ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
SFTPC / Surfactant Protein C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SFTPC / Surfactant Protein C ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
SFTPC / Surfactant Protein C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Lung Lavage Fluid, Tissue Homogenates
1 Plate/$750
SFTPC / Surfactant Protein C ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
SFTPC / Surfactant Protein C ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
SFTPC / Surfactant Protein C ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
SFTPC / Surfactant Protein C ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
SFTPC / Surfactant Protein C ELISA Kit
Select
Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$783
SFTPC / Surfactant Protein C ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
SFTPC / Surfactant Protein C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$715
SFTPC / Surfactant Protein C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.39 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SFTPC / Surfactant Protein C ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
125 - 8000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
SFTPC / Surfactant Protein C ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).