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SFTPB / Surfactant Protein B

surfactant protein B

SFTPB / Surfactant Protein B is the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.

Gene Name: surfactant protein B
Synonyms: SFTPB, 6 kDa protein, PSP-B, SFTP3, SP-B, SFTB3, SMDP1, Surfactant protein B
Target Sequences: NM_000542 NP_000533.3 P07988

Publications (2)

1
Recessive missense LAMP3 variant associated with defect in lamellar body biogenesis and fatal neonatal interstitial lung disease in dogs. Kati J Dillard, Matthias Ochs, Julia E Niskanen, Meharji Arumilli, Jonas Donner, Kaisa Kyöstilä, Marjo K Hytönen, Marjukka Anttila, Hannes Lohi. PLoS genetics. 2020 Mar;16:e1008651. [Full Text Article] [PubMed:32150563] [PMC:PMC7082050] Related Antibodies: LS-B8081.
2
Physiologically variable ventilation in a rabbit model of asthma exacerbation. André Dos Santos Rocha, Roberta Südy, Ferenc Peták, Walid Habre. British journal of anaesthesia. 2020 December;125:1107-1116. [Full Text Article] [PubMed:33070949]

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Products
ELISA Kits (23)
Competitive EIA (2)
Custom (3)
Development Kit (1)
Sandwich (15)
Sandwich CLIA (2)
SFTPB / Surfactant Protein B (23)
Human (6)
Mouse (3)
Rat (8)
Bovine (1)
Dog (1)
Monkey (1)
Pig (2)
Rabbit (1)
Product Group
DevKit DuoPlus (1)
12 x 8-Well Microstrips (2)
96-Well Microplate (3)
96-Well Strip Plate (17)
Antibody Pair and Standard (1)
No (23)
Cell Culture Supernatants (4)
Cell Lysates (4)
Lung Lavage Fluid (3)
Plasma (16)
Serum (16)
Tissue Homogenates (10)
SFTPB / Surfactant Protein B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Dog
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$929
SFTPB / Surfactant Protein B ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$913
SFTPB / Surfactant Protein B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Lung Lavage Fluid, Plasma, Serum, Tissue Homogenates
1 Plate/$798
SFTPB / Surfactant Protein B ELISA Kit
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Sandwich
96-Well Microplate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
SFTPB / Surfactant Protein B ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$818
SFTPB / Surfactant Protein B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SFTPB / Surfactant Protein B ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
SFTPB / Surfactant Protein B ELISA Kit
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Sandwich
96-Well Strip Plate
Human
25 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
SFTPB / Surfactant Protein B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Lung Lavage Fluid, Tissue Homogenates
1 Plate/$856
SFTPB / Surfactant Protein B ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
SFTPB / Surfactant Protein B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
SFTPB / Surfactant Protein B ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
SFTPB / Surfactant Protein B ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
SFTPB / Surfactant Protein B ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
SFTPB / Surfactant Protein B ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
SFTPB / Surfactant Protein B ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
0.313 - 20 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
SFTPB / Surfactant Protein B ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
1.563 - 100 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
SFTPB / Surfactant Protein B ELISA Kit
Select
Sandwich
96-Well Microplate
Pig
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
SFTPB / Surfactant Protein B ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
SFTPB / Surfactant Protein B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SFTPB / Surfactant Protein B ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Lung Lavage Fluid, Tissue Homogenates
500 Wells/$1,305; 1000 Wells/$1,952
SFTPB / Surfactant Protein B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
1.87 - 120 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$1,041
SFTPB / Surfactant Protein B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
3.12 - 200 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$1,041
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).