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Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
Gene Name: | frizzled-related protein |
Synonyms: | FRZB, FRZB-1, FIZ, FRE, FRITZ, Fritz and frizzled, Frizzled homolog-related, FRP-3, FRZB-PEN, HFIZ, FRP, FZRB, SFRP-3, SRFP3, OS1, Frezzled, Frizzled related protein 3, Frizzled-related protein, Frizzled-related protein 1, FRZB1, SFRP3 |
Target Sequences: | NM_001463 NP_001454.2 Q92765 |
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