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Necessary for the splicing of pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively.
Gene Name: | Splicing factor 3B, 14 kDa subunit |
Synonyms: | SF3B6, HSPC175, p14, SAP14, SF3B14, SF3B14a, CGI-110, Ht006, SF3b 14 kDa subunit |
Target Sequences: | NM_016047 NP_057131.1 Q9Y3B4 |
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