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SF3B4
splicing factor 3b, subunit 4, 49kDa
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
| Gene Name: | splicing factor 3b, subunit 4, 49kDa |
| Synonyms: | SF3B4, AFD1, Hsh49, SAP 49, Spliceosomal protein, SF3b50, SAP49, SF3b49, Splicing factor 3B subunit 4 |
| Target Sequences: | NM_005850 NP_005841.1 Q15427 |
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