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SF3B2
splicing factor 3b, subunit 2, 145kDa
SF3B2 is subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.
| Gene Name: | splicing factor 3b, subunit 2, 145kDa |
| Synonyms: | SF3B2, Cus1, SAP 145, SAP145, SF3B145, Splicing factor 3B subunit 2, SF3b150 |
| Target Sequences: | BC000401 AAH00401.2 Q13435 |
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