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Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Gene Name: | splicing factor 3b, subunit 1, 155kDa |
Synonyms: | SF3B1, Hsh155, MDS, PRP10, PRPF10, SAP 155, Splicing factor 3B subunit 1, SAP155, SF3b155 |
Target Sequences: | NM_012433 NP_036565.2 O75533 |
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