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SF3A1 / SF3A120

splicing factor 3a, subunit 1, 120kDa

Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.

Gene Name:	splicing factor 3a, subunit 1, 120kDa
Synonyms:	SF3A1, Pre-mRNA processing 21, PRPF21, SAP 114, SAP114, SF3A120, Splicing factor 3 subunit 1, Splicing factor 3A subunit 1, PRP21
Target Sequences:	NM_005877 NP_005868.1 Q15459

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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