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Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA.
Gene Name: | SET domain and mariner transposase fusion gene |
Synonyms: | SETMAR, HsMar1, METNASE |
Target Sequences: | NM_006515 NP_006506.3 Q53H47 |
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