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SETD8 / SET8

SET domain containing (lysine methyltransferase) 8

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.

Gene Name: SET domain containing (lysine methyltransferase) 8
Synonyms: SETD8, KMT5A, Lysine N-methyltransferase 5A, PR/SET07, PRSET7, SET8, H4-K20-HMTase SETD8, PR-Set7, SET07
Target Sequences: NM_020382 NP_065115.3 Q9NQR1

Publications (1)

1
An epigenetic regulator-related score (EpiScore) predicts survival in patients with diffuse large B cell lymphoma and identifies patients who may benefit from epigenetic therapy. Szablewski V, Bret C, Kassambara A, Devin J, Cartron G, Costes-Martineau V, Moreaux J. Oncotarget. 2018 April;9:19079-19099. (Human) [Full Text Article] [PubMed:29721185] [PMC:PMC5922379] Related Antibodies: LS-B5237.

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Proteins (4)
Over-Expression Lysate (2)
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SETD8 / SET8 (4)
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His, N-Terminal (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Purified (1)
SETD8 / SET8 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
39 kDa
20 µg/$150
SETD8 / SET8 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
39 kDa
100 µg/$494
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E. coli
None
18.2 kDa
100 µg/$721
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E. coli
His, N-Terminal
42.9 kDa
50 µg/$419
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).