SETD8 / SET8

SET domain containing (lysine methyltransferase) 8

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

SETD8 / SET8 (4)

Publications

No (4)

Tag

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Purification

Purified (1)

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Human SETD8 / SET8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91246

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39 kDa

Price:

20 µg/$150

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SETD8 / SET8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101662

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39 kDa

Price:

100 µg/$494

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Human SETD8 / SET8 Protein (Recombinant) (Lys195-His352) - LS-G138021

Source:

E. coli

Tag:

None

Molecular Weight:

18.2 kDa

Price:

100 µg/$721

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Human SETD8 / SET8 Protein (Recombinant His, N-Terminal) - LS-G143998

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

42.9 kDa

Price:

50 µg/$419

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