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Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.
Gene Name: | SERTA domain containing 2 |
Synonyms: | SERTAD2, KIAA0127, Sei-2, SERTA domain containing 2, TRIP-Br2 |
Target Sequences: | D50917 BAA09476.2 Q14140 |
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