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SERPING1 / C1 Inhibitor

serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.

Gene Name: serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
Synonyms: SERPING1, C1-inhibiting factor, C1IN, C1 Inh, C1-INH, C1INH, C1NH, C1 Inhibitor, HAE1, HAE2, Plasma protease C1 inhibitor, C1 esterase inhibitor, Serpin G1
Target Sequences: NM_000062 NP_000053.2 P05155

Publications (1)

1
C1-inactivator is upregulated in glioblastoma. Förnvik K, Maddahi A, Persson O, Osther K, Salford LG, Nittby Redebrandt H. PloS one. 2017 September;12:e0183086. (Human) [Full Text Article] [PubMed:28880870] [PMC:PMC5589086] Related Antibodies: LS-C192710.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).