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SERPINE1 / PAI-1

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

SERPINE1 / PAI-1 is a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Family/Subfamily: Serine Protease Inhibitor
Synonyms: SERPINE1, PAI1, PLANH1, PAI-1, Serpin E1
Target Sequences: NM_000602 NP_000593.1 P05121

Publications (1)

1
BDNF-TrkB signaling through Erk1/2 MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids. Revest JM, Le Roux A, Roullot-Lacarrière V, Kaouane N, Vallée M, Kasanetz F, Rougé-Pont F, Tronche F, Desmedt A, Piazza PV. Molecular psychiatry. 2014 19:1001-9. (WB; Rat) [Full Text Article] [PubMed:24126929] [PMC:PMC4195976] Related Antibodies: LS-C81062.

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Products
Proteins (25)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (5)
Recombinant (19)
SERPINE1 / PAI-1 (25)
No (25)
6His, C-terminus (4)
6His, N-terminus (3)
GST (1)
GST, N-terminus (1)
His (3)
His, N-Terminal (1)
His-S (1)
His-SUMO (2)
His-T7 (2)
Myc-DDK (Flag) (5)
Human (12)
Mouse (9)
Rat (2)
293T Cells (2)
E. coli (8)
HEK 293 Cells (6)
Human Cells (3)
Mammalian Cells (2)
Wheat Germ Extract (2)
Yeast (1)
Purified (5)
Low endotoxin level (6)
Biologically active (3)
SERPINE1 / PAI-1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
SERPINE1 / PAI-1 Protein
Select
E. coli
His
Biologically active
100 µg/$361; 500 µg/$739; 20 µg/$261
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.7kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
SERPINE1 / PAI-1 Protein - Recombinant Plasminogen Activator Inhibitor 1 By SDS-PAGE
Select
E. coli
His-T7
31.7 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
SERPINE1 / PAI-1 Protein - 12.5% SDS-PAGE of human SERPINE1 stained with Coomassie Blue
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Wheat Germ Extract
GST
69.85 kDa
10 µg/$479; 25 µg/$670
SERPINE1 / PAI-1 Protein
Select
Yeast
His
44.95 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
Select
E. coli
His-SUMO
58.92 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
SERPINE1 / PAI-1 Protein
Select
E. coli
His-SUMO
58.61 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
Select
HEK 293 Cells
6His, N-terminus
44 kDa
100 µg/$298
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HEK 293 Cells
6His, N-terminus
44 kDa
200 µl/$283
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None
Biologically active
42.7 kD
10 µg/$476
SERPINE1 / PAI-1 Protein - Purified recombinant protein SERPINE1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
42.7 kDa
20 µg/$1,107
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Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
44.2 kDa
50 µg/$854; 1 mg/$5,281
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
42.7 kDa
2 µg/$268; 10 µg/$349
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.82kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
SERPINE1 / PAI-1 Protein
Select
HEK 293 Cells
His, N-Terminal
~45 kDa
10 µg/$289; 200 µg/$646; 50 µg/$360
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.8 kDa
10 µg/$317; 50 µg/$524
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.7 kDa
10 µg/$317; 50 µg/$524
SERPINE1 / PAI-1 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
6His, N-terminus
44 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
SERPINE1 / PAI-1 Protein - Recombinant Plasminogen Activator Inhibitor 1 By SDS-PAGE
Select
E. coli
His-T7
46.5 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
SERPINE1 / PAI-1 Protein - Recombinant Plasminogen Activator Inhibitor 1 By SDS-PAGE
Select
E. coli
His-S
48.4 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
Select
293T Cells
Myc-DDK (Flag)
45.06 kDa
20 µg/$150
SERPINE1 / PAI-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
43.4 kDa
20 µg/$150
SERPINE1 / PAI-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
43.4 kDa
100 µg/$494
SERPINE1 / PAI-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
45.06 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).