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SERPIND1 / Heparin Cofactor 2

serpin peptidase inhibitor, clade D (heparin cofactor), member 1

Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.

Gene Name:	serpin peptidase inhibitor, clade D (heparin cofactor), member 1
Synonyms:	SERPIND1, D22S673, HCII, HLS2, HC-II, HC2, Leuserpin 2, LS2, HCF2, Heparin cofactor 2, THPH10, Protease inhibitor leuserpin-2, Serpin D1
Target Sequences:	NM_000185 NP_000176.2 P05546

Publications (1)

Salivary proteome profiling of oral squamous cell carcinoma in a Hungarian population. Csosz É, Márkus B, Darula Z, Medzihradszky KF, Nemes J, Szabó E, Tozsér J, Kiss C, Márton I. FEBS open bio. 2018 February;8:556-569. [Full Text Article] [PubMed:29632809] [PMC:PMC5881539]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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