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SERPINB1

serpin peptidase inhibitor, clade B (ovalbumin), member 1

SERPINB1 is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants.

Gene Name: serpin peptidase inhibitor, clade B (ovalbumin), member 1
Synonyms: SERPINB1, Anti-elastase, EI, LEI, Leukocyte elastase inhibitor, Peptidase inhibitor 2, PI-2, MNEI, ELANH2, M/NEI, PI2, Serpin B1
Target Sequences: NM_030666 NP_109591.1 P30740

Publications (2)

1
Circulating SerpinB1 levels and clinical features in patients with type 2 diabetes. Takebayashi K, Hara K, Terasawa T, Naruse R, Suetsugu M, Tsuchiya T, Inukai T. BMJ open diabetes research & care. 2016 November;4:e000274. [Full Text Article] [PubMed:27933185] [PMC:PMC5128937]
2
Association between circulating SerpinB1 levels and insulin sensitivity in Japanese with type 2 diabetes: A single-center, cross-sectional, observational study. Mayu Kyohara, Daisuke Miyashita, Ryota Inoue, Kuniyuki Nishiyama, Takahiro Tsuno, Tomoko Okuyama, Yu Togashi, Yasuo Terauchi, Jun Shirakawa. PloS one. 2022 November;17:e0276915. [Full Text Article] [PubMed:36331940] [PMC:PMC9635728]

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).