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SERPINA1 / Alpha 1 Antitrypsin

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).

Gene Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Synonyms: SERPINA1, A1A, A1AT, AAT, Alpha 1 Antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Alpha-1-antitrypsin, Alpha1AT, PRO2275, Alpha-1-antitrypsin null, PI1, Serpin A1, Alpha 1 AT
Target Sequences: K02212 AAB59495.1 P01009

Publications (5)

1
Skeletal muscle lipogenic protein expression is not different between lean and obese individuals: a potential factor in ceramide accumulation. Thrush AB, Brindley DN, Chabowski A, Heigenhauser GJ, Dyck DJ. The Journal of clinical endocrinology and metabolism. 2009 94:5053-61. [PubMed:19837942]
2
Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Dougan SK, Hu CC, Paquet ME, Greenblatt MB, Kim J, Lilley BN, Watson N, Ploegh HL. Molecular and cellular biology. 2011 31:1145-59. (WB, IP; Mouse) [PubMed:21220515] [PMC:PMC3067910]
3
Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control. Klemm EJ, Spooner E, Ploegh HL. The Journal of biological chemistry. 2011 286:37602-14. [PubMed:21857022] [PMC:PMC3199505]
4
Analysis of proteins in human gingival crevicular fluid by mass spectrometry. Kido J, Bando M, Hiroshima Y, Iwasaka H, Yamada K, Ohgami N, Nambu T, Kataoka M, Yamamoto T, Shinohara Y, Sagawa I, Nagata T. Journal of periodontal research. 2012 47:488-99. (WB; Human) [PubMed:22220998]
5
Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation. Yost CC, Schwertz H, Cody MJ, Wallace JA, Campbell RA, Vieira-de-Abreu A, Araujo CV, Schubert S, Harris ES, Rowley JW, Rondina MT, Fulcher JM, Koening CL, Weyrich AS, Zimmerman GA. The Journal of clinical investigation. 2016 126:3783-3798. (WB; Human) [Full Text Article] [PubMed:27599294]
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ELISA Kits (28)
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SERPINA1 / Alpha 1 Antitrypsin (28)
Human (12)
Mouse (5)
Rat (5)
Monkey (1)
Pig (2)
Rabbit (1)
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12 x 8-Well Microstrips (1)
96-Well Microplate (6)
96-Well Strip Plate (17)
Antibody Pair and Standard (3)
No (28)
Cell Culture Supernatants (8)
Cell Lysates (6)
EDTA Plasma (1)
Heparin Plasma (1)
Plasma (23)
Serum (24)
Tissue Homogenates (8)
Urine (1)
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
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Sandwich
96-Well Microplate
Rat
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
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Sandwich
96-Well Microplate
Pig
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$863
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$863
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
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Sandwich
96-Well Microplate
Human
2.048 - 500 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$588
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$818
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
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Sandwich
96-Well Microplate
Human
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
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Sandwich
96-Well Microplate
Mouse
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
7.81 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$856
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
0.55 - 400 ng/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$968
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$798
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$783
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
0.625 - 40 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
10 - 250 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Rat
10 - 250 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$760
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
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Development Kit
Antibody Pair and Standard
Human
12.5 - 800 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,229; 1000 Wells/$1,826
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Mouse
62.4 - 4000 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,254; 1000 Wells/$1,867
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Rat
15.62 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
500 Wells/$1,305; 1000 Wells/$1,952
SERPINA1 / Alpha 1 Antitrypsin ELISA Kit
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Sandwich
Human
1.56 - 100 ng/ml
Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum, Urine
1 Plate/$795
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).