SENP6

SUMO1/sentrin specific peptidase 6

Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

SENP6 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

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Human (2)

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293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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SENP6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113106

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

126 kDa

Price:

100 µg/$710

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Human SENP6 Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G62135

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SENP6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90141

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

126 kDa

Price:

20 µg/$215

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