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Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1.
Gene Name: | SUMO1/sentrin/SMT3 specific peptidase 2 |
Family/Subfamily: | Protease , Cysteine C48 |
Synonyms: | SENP2, SMT3-specific isopeptidase 2, SMT3IP2, AXAM2, KIAA1331, Sentrin-specific protease 2 |
Target Sequences: | NM_021627 NP_067640.2 Q9HC62 |
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