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The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. An antibacterial activity has been found for a antimicrobial peptide isolated from this protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20.
Gene Name: | semenogelin II |
Synonyms: | SEMG2, Semenogelin II, Semenogelin 2, Semenogelin-2, SGII |
Target Sequences: | NM_003008 NP_002999.1 Q02383 |
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