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Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Gene Name: | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) |
Synonyms: | SEMA7A, CD108, CD108 antigen, CDw108, JMH, JMH blood group antigen, H-SEMA-K1, H-Sema-L, Sema K1, SEMAL, Semaphorin-7A, Semaphorin-L, Sema L, SEMAK1, Semaphorin K1, Semaphorin L, Semaphorin-K1 |
Target Sequences: | NM_003612 NP_003603.1 O75326 |
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