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SEMA7A / Semaphorin 7A

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.

Gene Name: semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
Synonyms: SEMA7A, CD108, CD108 antigen, CDw108, JMH, JMH blood group antigen, H-SEMA-K1, H-Sema-L, Sema K1, SEMAL, Semaphorin-7A, Semaphorin-L, Sema L, SEMAK1, Semaphorin K1, Semaphorin L, Semaphorin-K1
Target Sequences: NM_003612 NP_003603.1 O75326

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).