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SEMA3F / Semaphorin 3F

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993 [PubMed 8269517]). Sequence comparisons have grouped the secreted semaphorins into 3 general classes, all of which also have an immunoglobulin domain. The semaphorin III family, consisting of human semaphorin III (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993 [PubMed 8402908]) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995 [PubMed 7637782]), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.

Gene Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Synonyms: SEMA3F, Semaphorin III/F, Semaphorin IV, Semaphorin-3F, Sema III/F, Sema IV, SEMA-IV, SEMA4, SEMAK
Target Sequences: NM_004186 NP_004177.3 Q13275

Publications (3)

1
Semaphorin 3F signaling actively retains neutrophils at sites of inflammation. Tracie Plant, Suttida Eamsamarng, Manuel A Sanchez-Garcia, Leila Reyes, Stephen A Renshaw, Patricia Coelho, Ananda S Mirchandani, Jessie-May Morgan, Felix E Ellett, Tyler Morrison, Duncan Humphries, Emily R Watts, Fiona Murphy, Ximena L Raffo-Iraolagoitia, Ailiang Zhang, Jenna L Cash, Catherine Loynes, Philip M Elks, Freek Van Eeden, Leo M Carlin, Andrew Jw Furley, Moira Kb Whyte, Sarah R Walmsley. The Journal of clinical investigation. 2020 Jun;130:3221-3237. [Full Text Article] [PubMed:32191647] [PMC:PMC7259996] Related Antibodies: LS-C135015.
2
The antiepileptic effect of Gastrodiae Rhizoma through modulating overexpression of mTOR and attenuating astrogliosis in pilocarpine mice model. Ka Lai Yip, Chi Man Koon, Zi Yi Chen, Ping Chook, Ping Chung Leung, Steven Schachter, Wai Hong Leung, Chung Tong Mok, Howan Leung. Epilepsia open. 2020 Dec;5:50-60. [Full Text Article] [PubMed:32140643] [PMC:PMC7049815]
3
Semaphorin 3F Modulates Corneal Lymphangiogenesis and Promotes Corneal Graft Survival. Tristan Reuer, Ann-Charlott Schneider, Bertan Cakir, Anima D Bühler, Johanna M Walz, Thabo Lapp, Clemens Lange, Hansjürgen Agostini, Günther Schlunck, Claus Cursiefen , Thomas Reinhard, Felix Bock , Andreas Stahl. The Breast : official journal of the European Society of Mastology. 2018 Oct;59:5277-5284. [Full Text Article] [PubMed:30383199] Related Antibodies: LS-C135015.

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Proteins (5)
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SEMA3F / Semaphorin 3F (5)
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His, N-Terminal (1)
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SEMA3F / Semaphorin 3F Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Mammalian Cells
6His, N-terminus
90.5kDa
100 µg/$1,266; 20 µg/$506; 1 mg/$4,627
SEMA3F / Semaphorin 3F Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
88.2 kDa
100 µg/$494
SEMA3F / Semaphorin 3F Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
88.2 kDa
20 µg/$150
SEMA3F / Semaphorin 3F Protein - Recombinant Semaphorin 3F By SDS-PAGE
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E. coli
His, N-Terminal
16.6 kDa
10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934
SEMA3F / Semaphorin 3F Protein - Recombinant Semaphorin 3F By SDS-PAGE
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E. coli
His
21.9 kDa
10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).