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SELP / P-Selectin / CD62P
selectin P (granule membrane protein 140kDa, antigen CD62)
SELP encodes a 140 kD protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.
| Gene Name: | selectin P (granule membrane protein 140kDa, antigen CD62) |
| Synonyms: | SELP, CD62P, CD62, GMP-140, GMRP, Granule membrane protein 140, LECAM3, P-selectin, PSEL, CD62P antigen, GMP140, Granulocyte membrane protein, GRMP, PADGEM |
| Target Sequences: | NM_003005 NP_002996.2 |
Publications (3)
1
Targeting P-selectin blocks neuroblastoma growth. Nolo R, Herbrich S, Rao A, Zweidler-McKay P, Kannan S, Gopalakrishnan V, ,. Oncotarget. 2017 8:86657-86670. (IP; Human)
[Full Text Article]
[PubMed:29156825]
Related Antibodies: LS-B3656.
2
Chronic Embolic Pulmonary Hypertension Caused by Pulmonary Embolism and Vascular Endothelial Growth Factor Inhibition. Neto-Neves EM, Brown MB, Zaretskaia MV, Rezania S, Goodwill AG, McCarthy BP, Persohn SA, Territo PR, Kline JA. The American journal of pathology. 2017 April;187:700-712. [Full Text Article]
[PubMed:28183533]
[PMC:PMC5397717]
3
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. Marcus Ruscetti, John P Morris th, Riccardo Mezzadra, James Russell, Josef Leibold, Paul B Romesser, Janelle Simon, Amanda Kulick, Yu-Jui Ho, Myles Fennell, Jinyang Li, Robert J Norgard, John E Wilkinson, Direna Alonso-Curbelo, Ramya Sridharan, Daniel A Heller, Elisa de Stanchina, Ben Z Stanger, Charles J Sherr, Scott W Lowe. Cell. 2020 April;181:424-441.e21. [Full Text Article]
[PubMed:32234521]
[PMC:PMC7278897]
☰ Filters
Products
Proteins
(17)
Type
Over-Expression Lysate
(2)
Recombinant
(15)
Target
SELP / P-Selectin / CD62P
(17)
Application
SDS-PAGE
(1)
Publications
No
(17)
Tag
6His, C-terminus
(1)
Fc, C-terminus
(3)
GST
(1)
His
(6)
His-AVI, C-terminus
(1)
His-T7
(1)
Human IgG Fc, C-terminus
(1)
Myc-DDK (Flag)
(3)
Species
Human
(11)
Mouse
(4)
Rat
(1)
Source
293T Cells
(1)
E. coli
(5)
HEK 293 Cells
(4)
Human
(2)
Human Cells
(2)
Mammalian Cells
(2)
Wheat Germ Extract
(1)
Purification
Purified
(5)
Low Endotoxin Level
Low endotoxin level
(9)
Biologically Active
Biologically active
(1)
HEK 293 Cells
Human IgG Fc, C-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human SELP/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 971 amino acids and has a predicted molecular mass of 107 kDa. The apparent molecular mass of the reduced monomer is approximately 130-150 kDa in SDS-PAGE under reducing conditions due to glycosylation.
100 µg/$403; 1 mg/$1,745
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
81.3 kDa
100 µg/$532; 1 mg/$2,785
HEK 293 Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
107 kDa
100 µg/$532; 1 mg/$2,785
Mammalian Cells
His-AVI, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
75.2 kDa
20 µg/$416; 100 µg/$910
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
99.5 kDa
10 µg/$248; 50 µg/$317
Human
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
106.9 kDa
10 µg/$265; 50 µg/$373
SELP / P-Selectin / CD62P Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117615
HEK 293 Cells
Myc-DDK (Flag)
90.78 kDa
100 µg/$494
Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
80.8 kDa
10 µg/$266; 50 µg/$377
Wheat Germ Extract
GST
117.2 kDa
2 µg/$439
HEK 293 Cells
Myc-DDK (Flag)
86.2 kDa
20 µg/$1,107
293T Cells
Myc-DDK (Flag)
90.78 kDa
20 µg/$150
E. coli
153 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
16.94 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
74 kDa
100 µg/$793; 1 mg/$4,191
E. coli
His-T7
29.3 kDa
10 µg/$246; 50 µg/$299; 100 µg/$352; 200 µg/$442; 1 mg/$1,242; 500 µg/$882; 5 mg/$2,097; 2 mg/$1,391
E. coli
His
24.5 kDa
10 µg/$249; 50 µg/$307; 100 µg/$385; 200 µg/$482; 1 mg/$1,325; 500 µg/$962; 5 mg/$2,204; 2 mg/$1,480
E. coli
His
17.6 kDa
10 µg/$246; 50 µg/$299; 100 µg/$352; 200 µg/$442; 1 mg/$1,242; 500 µg/$882; 5 mg/$2,097; 2 mg/$1,391
E. coli
His
13.4 kDa
10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170
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