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Secretory Component

Secretory Component is a component of immunoglobulin A (IgA) which consists of a portion of the polymeric immunoglobulin receptor. Polymeric IgA binds to the polymeric immunoglobulin receptor on the basolateral surface of epithelial cells and is taken up into the cell via transcytosis. The receptor-IgA complex passes through the cellular compartments before being secreted on the luminal surface of the epithelial cells, still attached to the receptor. Proteolysis of the receptor occurs and the dimeric IgA molecule, along with the secretory component, are free to diffuse throughout the lumen.

Secretory Component Target Details

Target Name: Secretory Component

Publications (1)

1
Immune exclusion by naturally-acquired secretory IgA to the pneumococcal pilus-1. Ulrike Binsker, John A Lees, Alexandria J Hammond, Jeffrey N Weiser. The Journal of clinical investigation. 2019 Feb;130:927-941. [Full Text Article] [PubMed:31687974] [PMC:PMC6994158] Related Antibodies: LS-C45754.

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Secretory Component (1)
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Secretory Component ELISA Kit
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Sandwich
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Human
0.312 - 20 µg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$958
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).