SCUBE3

signal peptide, CUB domain, EGF-like 3

SCUBE3 is a member of the signal peptide, complement subcomponents C1r/C1s, Uegf, bone morphogenetic protein-1 and epidermal growth factor-like domain containing protein family. Overexpression of this gene in human embryonic kidney cells results in secretion of a glycosylated form of the protein that forms oligomers and tethers to the cell surface. This gene is upregulated in lung cancer tumor tissue compared to healthy tissue and is associated with loss of the epithelial marker E-cadherin and with increased expression of vimentin, a mesenchymal marker. In addition, the protein encoded by this gene is a transforming growth factor beta receptor ligand, and when secreted by cancer cells, it can be cleaved in vitro to release the N-terminal epidermal growth factor-like repeat domain and the C-terminal complement subcomponents C1r/C1s domain. Both the full length protein and C-terminal fragment can bind to the transforming growth factor beta type II receptor to promote the epithelial-mesenchymal transition and tumor angiogenesis. Alternative splicing results in multiple transcript variants.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

SCUBE3 (5)

Publications

No (5)

Tag

GST, N-terminus (2)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

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SCUBE3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106030

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.1 kDa

Price:

100 µg/$494

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Human SCUBE3 Protein (Recombinant GST, N-terminus) (aa401-499) - LS-G63831

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SCUBE3 Protein (Recombinant GST, N-terminus) (aa29-147) - LS-G63835

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SCUBE3 Protein (Recombinant His-T7) (aa807-993) - LS-G26262

Source:

E. coli

Tag:

His-T7

Molecular Weight:

25.5 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Human SCUBE3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92648

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.1 kDa

Price:

20 µg/$150

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