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SCRN1 / Secernin 1

secernin 1

Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium.

Gene Name:	secernin 1
Synonyms:	SCRN1, KIAA0193, Secernin-1, SES1, Secernin 1
Target Sequences:	NM_014766 NP_055581.3 Q12765

Publications (4)

Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer's disease. Drummond E, Nayak S, Faustin A, Pires G, Hickman RA, Askenazi M, Cohen M, Haldiman T, Kim C, Han X, Shao Y, Safar JG, Ueberheide B, Wisniewski T. Acta neuropathologica. 2017 June;133:933-954. (Human) [Full Text Article] [PubMed:28258398] [PMC:PMC5503748] Related Antibodies: LS-C162903.

Phosphorylated tau interactome in the human Alzheimer's disease brain. Eleanor Drummond, Geoffrey Pires, Claire MacMurray, Manor Askenazi, Shruti Nayak, Marie Bourdon, Jiri Safar, Beatrix Ueberheide, Thomas Wisniewski. Brain : a journal of neurology. 2020 September;143:2803-2817. [Full Text Article] [PubMed:32812023] [PMC:PMC7526722] Related Antibodies: LS-C162903.

Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies. Geoffrey Pires, Sacha McElligott, Shiron Drusinsky, Glenda Halliday, Marie-Claude Potier, Thomas Wisniewski, Eleanor Drummond. Acta neuropathologica communications. 2019 Dec;7:195. [Full Text Article] [PubMed:31796108] [PMC:PMC6892024] Related Antibodies: LS-C162903, LS-C338451.

The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse. Brendan J Houston, Liina Nagirnaja, D Jo Merriner, Anne E O'Connor, Hidenobu Okuda, Kenan Omurtag, Craig Smith, Kenneth I Aston, Donald F Conrad, Moira K O'Bryan. Developmental dynamics : an official publication of the American Association of Anatomists. 2021 July;250:922-931. [Full Text Article] [PubMed:33442887] [PMC:PMC9012169] Related Antibodies: LS-C338451.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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