SCOP / PHLPP

PH domain and leucine rich repeat protein phosphatase 1

Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.

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Products

Antibodies (18)

Type

Primary (18)

Target

SCOP / PHLPP (18)

Reactivity

Human (18)

Mouse (14)

Rat (14)

Application

IHC (4)

IHC-P (2)

WB (18)

ELISA (4)

ICC (8)

IF (2)

IP (1)

Peptide-ELISA (2)

Host

rabbit (18)

Product Group

IHCPlus (1)

Isotype

Ig (1)

IgG (12)

Clonality

polyclonal pc (18)

Format

APC Conjugated (1)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

PE Conjugated (1)

Unconjugated (13)

Epitope

C-Terminus (2)

aa1194-1243 (1)

aa531-560 (1)

Publications

No (18)

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SCOP / PHLPP Antibody LS-C146688

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

1 Each/$431

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IHC-plus™ SCOP / PHLPP Antibody LS-B8860

(4.0) Rating

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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SCOP / PHLPP Antibody LS-C754796

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

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SCOP / PHLPP Antibody LS-C750940

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$466

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SCOP / PHLPP Antibody (C-Terminus) LS-C126131

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

100 µg/$786

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SCOP / PHLPP Antibody (HRP) LS-C548727

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, WB

Format:

HRP Conjugated

Price:

100 µl/$1,017

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SCOP / PHLPP Antibody (Biotin) LS-C528637

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, WB

Format:

Biotin Conjugated

Price:

100 µl/$1,017

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SCOP / PHLPP Antibody (FITC) LS-C538584

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, WB

Format:

FITC Conjugated

Price:

100 µl/$1,017

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SCOP / PHLPP Antibody (PE) LS-C656739

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, WB

Format:

PE Conjugated

Price:

100 µl/$1,017

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SCOP / PHLPP Antibody (APC) LS-C518675

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal (APC) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, WB

Format:

APC Conjugated

Price:

100 µl/$1,017

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC

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SCOP / PHLPP Antibody LS-C778653

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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SCOP / PHLPP Antibody (aa1194-1243) LS-C199994

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal (aa1194-1243) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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SCOP / PHLPP Antibody LS-C807258

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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SCOP / PHLPP Antibody LS-C772753

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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SCOP / PHLPP Antibody LS-C342160

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

SCOP / PHLPP Antibody (aa531-560) LS-C97458

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal (aa531-560) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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SCOP / PHLPP Antibody LS-C411076

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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SCOP / PHLPP Antibody (C-Terminus) LS-C353819

Antibody:

SCOP / PHLPP Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

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