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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SCN5A / Nav1.5

sodium channel, voltage-gated, type V, alpha subunit

Scn5a encodes the alpha subunit of the type V voltage-gated sodium channel. These channels, composed of one alpha and one or two beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials. The alpha subunit alone has been shown to generate a functional channel in vitro, but it's kinetic properties are modulated by beta subunits. The type V channel has been shown to be tetrodotoxin-resistant. Scn5a null mice experience intrauterine lethality. Mutations in the SCN5A gene are responsible for several heart conditions, including the chromosome 3-linked form of long LQT and Brugada syndrome.

Gene Name: sodium channel, voltage-gated, type V, alpha subunit
Family/Subfamily: Ion Channel , Sodium channel - voltage-gated
Synonyms: SCN5A, CDCD2, CMPD2, HB1, HB2, HH1, HBBD, Nav1.5, IVF, RSKM2X, SCAL, Scn2x, LQT3, SSS1, MH1, VF1, PFHB1, RATRSKM2X, SkM2, CMD1E, ICCD, RH1, RSkM2
Target Sequences: NM_000335 NP_000326.2 Q14524

Publications (1)

1
Direct activation of the Mauthner cell by electric field pulses drives ultrarapid escape responses. Tabor KM, Bergeron SA, Horstick EJ, Jordan DC, Aho V, Porkka-Heiskanen T, Haspel G, Burgess HA. Journal of neurophysiology. 2014 112:834-44. (WB; Human) [Full Text Article] [PubMed:24848468] [PMC:PMC4122749] Related Antibodies: LS-C144743.

Filtered by: None
Target
SCN5A / Nav1.5 (37)
Reactivity
Human (37)
Mouse (18)
Rat (17)
Bat (4)
Bovine (4)
Chicken (4)
Chimpanzee (3)
Dog (10)
Gibbon (9)
Guinea pig (4)
Horse (10)
Monkey (15)
Pig (10)
Xenopus (4)
Zebrafish (4)
Application
IHC (10)
IHC-P (7)
WB (27)
ELISA (12)
ICC (1)
IF (2)
Peptide-ELISA (2)
Host
rabbit (34)
mouse (1)
goat (2)
Isotype
IgG (16)
IgM (1)
Clonality
monoclonal mc (1)
polyclonal pc (36)
Clone
4G8-1G7 (1)
Format
AP Conjugated (2)
APC Conjugated (2)
Azide-free (2)
Biotin Conjugated (5)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (2)
Unconjugated (16)
Epitope
aa42-70 (8)
Internal (6)
C-Terminus (4)
aa1856-1905 (4)
aa539-588 (4)
aa1021-1034 (1)
aa1548-1558 (1)
Publications
No (36)
Yes (1)
Showing 1-25 of 37 results

IHC-plus™ SCN5A / Nav1.5 Antibody (Internal, Biotin) LS-A109657
Rabbit Polyclonal to Human SCN5A / Nav1.5
Mouse, Dog, Rat, Pig, Horse, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-SCN5A / Nav1.5 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ SCN5A / Nav1.5 Antibody (Internal, FITC) LS-A109658
Rabbit Polyclonal to Human SCN5A / Nav1.5
Mouse, Dog, Rat, Pig, Horse, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl  $650.00
Anti-SCN5A / Nav1.5 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ SCN5A / Nav1.5 Antibody (Internal, AP) LS-A109655
Rabbit Polyclonal to Human SCN5A / Nav1.5
Mouse, Dog, Rat, Pig, Horse, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl  $650.00
Anti-SCN5A / Nav1.5 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ SCN5A / Nav1.5 Antibody (Internal, APC) LS-A109656
Rabbit Polyclonal to Human SCN5A / Nav1.5
Mouse, Dog, Rat, Pig, Horse, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-SCN5A / Nav1.5 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ SCN5A / Nav1.5 Antibody (Internal, PE) LS-A109660
Rabbit Polyclonal to Human SCN5A / Nav1.5
Mouse, Dog, Rat, Pig, Horse, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl  $650.00
Anti-SCN5A / Nav1.5 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ SCN5A / Nav1.5 Antibody (Internal, Azide-free, HRP) LS-A109659
Rabbit Polyclonal to Human SCN5A / Nav1.5
Mouse, Dog, Rat, Pig, Horse, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-SCN5A / Nav1.5 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ SCN5A / Nav1.5 Antibody (aa1548-1558) LS-B8
Goat Polyclonal to Human SCN5A / Nav1.5
Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-SCN5A / Nav1.5 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

SCN5A / Nav1.5 Antibody (aa539-588) LS-C109984
Rabbit Polyclonal to Human SCN5A / Nav1.5
Mouse, Rat, Human
WB
Unconjugated
100µl 0.5mg/ml  $385.00
SCN5A / Nav1.5 antibody Western blot of Fetal Muscle lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

SCN5A / Nav1.5 Antibody LS-C144743
Publications (1)
Publications (1)
Rabbit Polyclonal to Human SCN5A / Nav1.5
Human
IF, WB
Unconjugated
100µl  $275.00

SCN5A / Nav1.5 Antibody (aa1856-1905) LS-C30483
Rabbit Polyclonal (IgG) to Human SCN5A / Nav1.5
Xenopus, Chicken, Zebrafish, Pig, Horse, Mouse, Dog, Guinea pig, Bovine, Bat, Rat, Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $385.00
SVV620 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SCN5A / Nav1.5 Antibody (aa42-70) LS-C158925
Rabbit Polyclonal to Human SCN5A / Nav1.5
Human
WB
Unconjugated
400µl  $325.00
SCN5A Antibody western blot of K562 cell line lysates (35 ug/lane). The SCN5A antibody detected the SCN5A protein (arrow).

SCN5A / Nav1.5 Antibody (clone 4G8-1G7) LS-C179971
Mouse Monoclonal [clone 4G8-1G7] (IgM) to Human SCN5A / Nav1.5
Human
ICC, WB
Unconjugated
100µg 1mg/ml  $335.00
Figure A: Plasma membrane localization of Nav1.5 identified by 4G8:1G7 detected by anti-mouse Alexa Fluor-488 conjugated antibody; Figure B, DAP1 co-staining of cell nuclei

SCN5A / Nav1.5 Antibody (aa1021-1034) LS-C154846
Goat Polyclonal to Human SCN5A / Nav1.5
Human, Monkey
Peptide-ELISA
Unconjugated
100µg 0.5mg/ml  $335.00

SCN5A / Nav1.5 Antibody LS-C809030
Rabbit Polyclonal (IgG) to Human SCN5A / Nav1.5
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00

SCN5A / Nav1.5 Antibody LS-C153556
Rabbit Polyclonal to Human SCN5A / Nav1.5
Human
ELISA, IHC, WB
Unconjugated
100µg 100µl 1mg/ml  $315.00

SCN5A / Nav1.5 Antibody LS-C406014
Rabbit Polyclonal (IgG) to Human SCN5A / Nav1.5
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl 0.5mg/ml  $205.00; 60µl 0.5mg/ml  $235.00; 120µl 0.5mg/ml  $295.00; 200µl 0.5mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human ovarian cancer using SCN5A Polyclonal Antibody at dilution of 1:25.

SCN5A / Nav1.5 Antibody LS-C402772
Rabbit Polyclonal (IgG) to Human SCN5A / Nav1.5
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl 0.3mg/ml  $205.00; 60µl 0.3mg/ml  $235.00; 120µl 0.3mg/ml  $295.00; 200µl 0.3mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human ovarian cancer using SCN5A Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of paraffin-embedded Human ovarian cancer using SCN5A Polyclonal Antibody at dilution of 1:30.

SCN5A / Nav1.5 Antibody (aa42-70) LS-C324943
Rabbit Polyclonal (IgG) to Human SCN5A / Nav1.5
Human
ELISA, WB
Unconjugated
200µl  $590.00

SCN5A / Nav1.5 Antibody (aa42-70, Biotin) LS-C207629
Rabbit Polyclonal (IgG) to Human SCN5A / Nav1.5
Human
ELISA, WB
Biotin Conjugated
200µl  $740.00

SCN5A / Nav1.5 Antibody (aa42-70, FITC) LS-C207630
Rabbit Polyclonal (IgG) to Human SCN5A / Nav1.5
Human
ELISA, WB
FITC Conjugated
200µl  $740.00

SCN5A / Nav1.5 Antibody (aa42-70, APC) LS-C207628
Rabbit Polyclonal (IgG) to Human SCN5A / Nav1.5
Human
ELISA, WB
APC Conjugated
200µl  $740.00

SCN5A / Nav1.5 Antibody (aa42-70, AP) LS-C209054
Rabbit Polyclonal (IgG) to Human SCN5A / Nav1.5
Human
ELISA, WB
AP Conjugated
200µl  $740.00

SCN5A / Nav1.5 Antibody (aa42-70, PE) LS-C207631
Rabbit Polyclonal (IgG) to Human SCN5A / Nav1.5
Human
ELISA, WB
PE Conjugated
200µl  $740.00

SCN5A / Nav1.5 Antibody (aa42-70, Azide-free, HRP) LS-C207632
Rabbit Polyclonal (IgG) to Human SCN5A / Nav1.5
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl  $740.00

SCN5A / Nav1.5 Antibody LS-C753155
Rabbit Polyclonal (IgG) to Human SCN5A / Nav1.5
Human
ELISA, WB
Unconjugated
100µg  $355.00
Showing 1-25 of 37 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).