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SCN3B
sodium channel, voltage-gated, type III, beta subunit
Scn3b encodes one type of beta subunit found in voltage-gated sodium channels. These channels, composed of one alpha and one or two different beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials. Scn3b is considered an auxiliary subunit that modulates channel gating and targeting to the plasma membrane. Scn3b has been shown to be significantly upregulated in a model of neuropathic pain.
| Gene Name: | sodium channel, voltage-gated, type III, beta subunit |
| Family/Subfamily: | Ion Channel , Sodium channel - voltage-gated |
| Synonyms: | SCN3B, KIAA1158, HSA243396, SCNB3, Sodium channel subunit beta-3, Navbeta3, Sodium channel beta-3 subunit |
| Target Sequences: | NM_018400 NP_060870.1 Q9NY72 |
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