SCN1B

sodium channel, voltage-gated, type I, beta subunit

Scn1b encodes one type of beta subunit found in voltage-gated sodium channels. These channels, composed of one alpha and one or two different beta subunits, mediates changes in cell permeability to sodium ions that are essential for the generation of action potentials. Scn1b protein is comprised of an extracellular N-terminus and a single transmembrane domain. Scn1b is considered an auxiliary subunit that modulates channel gating as well as plasma membrane expression levels. At least two mRNA variants, resulting from intron retention in the longer form, have been reported. A mutation in the extracellular immunoglobulin domain of Scn1b protein has been linked to 'generalized epilepsy with febrile seizures plus type 1' (GEFS+1). Mutations in the Scn1b gene may also be responsible for severe myoclonic epilepsy in infancy (SME).

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Proteins (5)

Type

Over-Expression Lysate (4)

Recombinant (1)

Target

SCN1B (5)

Publications

No (5)

Tag

GST (1)

Myc-DDK (Flag) (4)

Species

Human (3)

Source

293T Cells (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human SCN1B Protein (Recombinant GST) (Full Length) - LS-G30327

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

49.61 kDa

Price:

2 µg/$439

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SCN1B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120692

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.5 kDa

Price:

100 µg/$494

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Human SCN1B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78869

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.3 kDa

Price:

20 µg/$150

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Human SCN1B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78868

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.5 kDa

Price:

20 µg/$150

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SCN1B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103486

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.3 kDa

Price:

100 µg/$494

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