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SART3 is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.
Gene Name: | squamous cell carcinoma antigen recognized by T cells 3 |
Synonyms: | SART3, DSAP1, KIAA0156, p100, p110(nrb), RP11-13G14, SART-3, TIP110, HSART-3, p110 |
Target Sequences: | NM_014706 NP_055521.1 Q15020 |
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