S100A8 / MRP8

S100 calcium binding protein A8

S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn2+ which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread.

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Products

Proteins (32)

Type

Over-Expression Cell Culture Supernatant (1)

Recombinant (31)

Target

S100A8 / MRP8 (32)

Publications

No (32)

Tag

6His, C-terminus (5)

6His, N-terminus (1)

GST (1)

GST, N-terminus (2)

His (8)

His, N-Terminal (5)

His, N-terminus (1)

His, N-terminus + His, C-terminus (1)

His,C-terminus (1)

His-S (3)

His-T7 (1)

Myc-DDK (Flag) (1)

Myc-DDK (Flag), C-terminus (1)

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Species

Bovine (1)

Human (17)

Mouse (9)

Pig (1)

Rabbit (1)

Rat (3)

Source

E. coli (23)

HEK 293 Cells (4)

Insect Cells (1)

Wheat Germ Extract (2)

Yeast (2)

Purification

Purified (4)

Supernatant (1)

Low Endotoxin Level

Low endotoxin level (7)

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Mouse S100A8 / MRP8 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G23113

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

12.16 kD

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Human S100A8 / MRP8 Protein (Recombinant His) (aa1-93) - LS-G14298

Source:

E. coli

Tag:

His

Molecular Weight:

12.4 kDa

Price:

10 µg/$290; 50 µg/$500; 200 µg/$997; 100 µg/$797; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329

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Human S100A8 / MRP8 Protein (Recombinant His,C-terminus) (Met1-Glu93) - LS-G138040

Source:

Insect Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

12.2 kDa

Price:

100 µg/$721

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Human S100A8 / MRP8 Protein (Recombinant GST, N-terminus) (aa1-92) - LS-G60022

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse S100A8 / MRP8 Protein (Recombinant His, N-terminus + His, C-terminus) - LS-G146298

Source:

E. coli

Tag:

His, N-terminus + His, C-terminus

Molecular Weight:

11.5kDa

Price:

20 µg/$270; 100 µg/$390

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Mouse S100A8 / MRP8 Protein (Recombinant Myc-DDK (Flag), C-terminus) (Full Length) - LS-G142155

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag), C-terminus

Molecular Weight:

10.7 kDa

Price:

20 µg/$1,224

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Human S100A8 / MRP8 Protein (Recombinant His, N-terminus) - LS-G145974

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

10.83 kDa

Price:

20 µg/$270; 100 µg/$390

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Human S100A8 / MRP8 Protein (Recombinant GST) (Full Length) - LS-G30303

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

35.97 kDa

Price:

10 µg/$479; 25 µg/$670

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Rat S100A8 / MRP8 Protein (Recombinant His) (Full Length) - LS-G23114

Source:

Yeast

Tag:

His

Molecular Weight:

12.11 kD

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Pig S100A8 / MRP8 Protein (Recombinant His-S) (aa1-89) - LS-G24494

Source:

E. coli

Tag:

His-S

Molecular Weight:

14.1 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Rabbit S100A8 / MRP8 Protein (Recombinant His-S) (aa1-89) - LS-G24495

Source:

E. coli

Tag:

His-S

Molecular Weight:

13.8 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

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Mouse S100A8 / MRP8 Protein (Recombinant His) (Full Length) - LS-G21154

Source:

E. coli

Tag:

His

Molecular Weight:

12.16 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Rat S100A8 / MRP8 Protein (Recombinant His) (Full Length) - LS-G21155

Source:

E. coli

Tag:

His

Molecular Weight:

14.2 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Mouse S100A8 / MRP8 Protein (Recombinant GST, N-terminus) - LS-G56504

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human S100A8 / MRP8 Protein (Over-Expression Cell Culture Supernatant His, N-Terminal) (Leu2-Glu93) - LS-G96769

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~11 kDa

Price:

200 µl/$283

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Human S100A8 / MRP8 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65136

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

10.7 kDa

Price:

20 µg/$1,107

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Human S100A8 / MRP8 Protein (Recombinant) - LS-G751

Source:

E. coli

Tag:

None

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Human S100A8 / MRP8 Protein (Recombinant His) (aa1-93) - LS-G140856

Source:

E. coli

Sequence Length:

93 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

10.23 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Human S100A8 / MRP8 Protein (Recombinant 6His, C-terminus) (Met1-Glu93) - LS-G138733

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

11.7 kDa

Price:

10 µg/$248; 50 µg/$317

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Mouse S100A8 / MRP8 Protein (Recombinant 6His, C-terminus) (Met1-Glu89) - LS-G139872

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

11.3 kDa

Price:

10 µg/$288; 50 µg/$436

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Mouse S100A8 / MRP8 Protein (Recombinant His) - LS-G1309

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Mouse S100A8 / MRP8 Protein (Recombinant 6His, C-terminus) (Met1-Glu89) - LS-G39843

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

11.3kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human S100A8 / MRP8 Protein (Recombinant His, N-Terminal) (Leu2-Glu93) - LS-G96770

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

14 kDa

Price:

10 µg/$265; 100 µg/$365; 250 µg/$518; 50 µg/$315

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Human S100A8 / MRP8 Protein (Recombinant His, N-Terminal) (Leu2-Glu93) - LS-G96768

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~11 kDa

Price:

10 µg/$289; 200 µg/$646; 50 µg/$360

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Human S100A8 / MRP8 Protein (Recombinant 6His, C-terminus) (Met1-Glu93) - LS-G39192

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

11.7kD

Price:

10 µg/$248; 50 µg/$321; 500 µg/$905; 1 mg/$1,203

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