RSPO3

R-spondin 3

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

RSPO3 (7)

Publications

No (7)

Tag

Fc/6His,C-terminus (1)

Fc-6His, C-terminus (1)

His (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (6)

Source

293T Cells (1)

CHO Cells (1)

E. coli (1)

HEK 293 Cells (1)

Human Cells (2)

Mammalian Cells (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (4)

Biologically Active

Biologically active (1)

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Human RSPO3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88540

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.7 kDa

Price:

20 µg/$150

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Human RSPO3 Protein (Recombinant His-T7) (aa22-272) - LS-G26172

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.0 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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RSPO3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102086

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.7 kDa

Price:

100 µg/$494

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Human RSPO3 Protein (Recombinant His) (Met1-Val146) - LS-G97841

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

15.3 kDa

Price:

50 µg/$556

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Human RSPO3 Protein (Recombinant) - LS-G106

Source:

CHO Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

26.9 kDa

Price:

5 µg/$268; 20 µg/$349

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Human RSPO3 Protein (Recombinant Fc/6His,C-terminus) (Gln22-His272) - LS-G139764

Source:

Mammalian Cells

Tag:

Fc/6His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

56.3 kDa

Price:

10 µg/$288; 50 µg/$436

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Human RSPO3 Protein (Recombinant Fc-6His, C-terminus) (Gln22-His272) - LS-G39369

Source:

Human Cells

Tag:

Fc-6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

56.3kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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