Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Gene Name: | ribosomal RNA processing 8, methyltransferase, homolog (yeast) |
Synonyms: | RRP8, Cerebral protein 1, KIAA0409, Nucleomethylin, RRP8 methyltransferase homolog, NML |
Target Sequences: | NM_015324 NP_056139.1 O43159 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.