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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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RRP8

ribosomal RNA processing 8, methyltransferase, homolog (yeast)

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

Gene Name: ribosomal RNA processing 8, methyltransferase, homolog (yeast)
Synonyms: RRP8, Cerebral protein 1, KIAA0409, Nucleomethylin, RRP8 methyltransferase homolog, NML
Target Sequences: NM_015324 NP_056139.1 O43159

Filtered By: None
Target
RRP8 (17)
Reactivity
Human (17)
Mouse (1)
Bovine (2)
Dog (1)
Guinea pig (2)
Horse (2)
Pig (1)
Rabbit (2)
Application
IHC (8)
IHC-P (6)
WB (16)
ELISA (2)
IF (1)
IP (1)
Peptide-ELISA (1)
Host
rabbit (16)
mouse (1)
Isotype
IgG (4)
Clonality
polyclonal pc (17)
Format
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (11)
Epitope
aa100-149 (4)
aa89-138 (4)
240-320 aa, Internal (1)
Internal (1)
Leu310 (1)
N-Terminus (1)
aa1-50 (1)
aa271-320 (1)
aa406-456 (1)
Publications
No (17)
Showing 1-17 of 17 results

RRP8 Antibody (aa89-138) IHC-plus™ LS-B11561
Rabbit Polyclonal to Human RRP8
Human
IHC IHC-P WB
Unconjugated
50µg  $485.00
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

RRP8 Antibody (aa89-138, HRP) LS-C475899
Rabbit Polyclonal to Human RRP8
Human
IHC IHC-P WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

RRP8 Antibody (aa89-138, Biotin) LS-C475897
Rabbit Polyclonal to Human RRP8
Human
IHC IHC-P WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

RRP8 Antibody (aa89-138, FITC) LS-C475898
Rabbit Polyclonal to Human RRP8
Human
IHC IHC-P WB
FITC Conjugated
100µl 1mg/ml  $385.00
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

RRP8 Antibody LS-C752958
Rabbit Polyclonal (IgG) to Human RRP8
Human
ELISA IF IHC WB
Unconjugated
100µg  $355.00

RRP8 Antibody (240-320 aa, Internal) LS-C382665
Rabbit Polyclonal (IgG) to Human RRP8
Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of Cerebral 1 antibody
Western blot of Cerebral 1 antibody

RRP8 Antibody (Leu310) LS-C177358
Rabbit Polyclonal to Human RRP8
Human
IHC IHC-P WB
Unconjugated
100µl  $345.00
IHC of Cerebral 1 (L310) pAb in paraffin-embedded human breast carcinoma tissue.
Western blot of Cerebral 1 (L310) pAb in extracts from MCF-7 cells.
IHC of Cerebral 1 (L310) pAb in paraffin-embedded human breast carcinoma tissue.
Western blot of Cerebral 1 (L310) pAb in extracts from MCF-7 cells.

RRP8 Antibody (Internal) LS-C368896
Rabbit Polyclonal to Human RRP8
Human
IHC IHC-P WB
Unconjugated
30µl 1mg/ml  $205.00; 100µl 1mg/ml  $245.00; 200µl 1mg/ml  $305.00
Immunohistochemical analysis of RRP8 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected with HRP and DAB as chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Western blot analysis of RRP8 expression in HeLa (A); MCF7 (B); HeLa (C) whole cell lysates.
Immunohistochemical analysis of RRP8 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected with HRP and DAB as chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Western blot analysis of RRP8 expression in HeLa (A); MCF7 (B); HeLa (C) whole cell lysates.

RRP8 Antibody (aa271-320) LS-C119843
Rabbit Polyclonal (IgG) to Human RRP8
Human
Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of lysates from MCF-7 cells, using HUCE1 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from MCF-7 cells, using HUCE1 Antibody. The lane on the right is blocked with the synthesized peptide.

RRP8 Antibody (N-Terminus) LS-C131113
Rabbit Polyclonal to Human RRP8
Human
WB
Unconjugated
100µl  $530.00

RRP8 Antibody (aa1-50) LS-C290841
Rabbit Polyclonal to Human RRP8
Rabbit, Guinea pig, Bovine, Horse, Human
WB
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human RRP8 by Western Blot. Samples: Whole cell lysate (50 ug) from 293T, HeLa, and Jurkat cells. Antibodies: Affinity purified rabbit anti-RRP8 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Detection of Human RRP8 by Western Blot. Samples: Whole cell lysate (50 ug) from 293T, HeLa, and Jurkat cells. Antibodies: Affinity purified rabbit anti-RRP8 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

RRP8 Antibody (aa100-149) LS-C170504
Rabbit Polyclonal to Human RRP8
Human
WB
Unconjugated
50µg  $365.00
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

RRP8 Antibody (aa100-149, HRP) LS-C475902
Rabbit Polyclonal to Human RRP8
Human
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

RRP8 Antibody (aa100-149, Biotin) LS-C475900
Rabbit Polyclonal to Human RRP8
Human
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

RRP8 Antibody (aa100-149, FITC) LS-C475901
Rabbit Polyclonal to Human RRP8
Human
WB
FITC Conjugated
100µl 1mg/ml  $385.00
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

RRP8 Antibody (aa406-456) LS-C290844
Rabbit Polyclonal to Human RRP8
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Human
IP
Unconjugated
100µl 1mg/ml  $395.00

RRP8 Antibody LS-C308622
Mouse Polyclonal (IgG) to Human RRP8
Human
WB
Unconjugated
50µg  $560.00
Showing 1-17 of 17 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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